Hansen's fingerprints in bone marrow histiocytes
نویسندگان
چکیده
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 47-year-old man from a region endemic for leprosy presented with a 1-month history of high grade fever and red, raised skin lesions on the upper limbs. He had multiple tender papules and nodules on his forearm and thigh along with sensory loss and thickening of nerves. The complete blood count revealed normocytic normochromic red blood cells, a leukocyte count of 15.6×10 9 /L with 81% neutrophils, and a platelet count of 361×10 9 /L. A bone marrow aspiration was performed to investigate the fever. The myeloid to erythroid ratio was 1.5:1. Erythroid and myeloid series were within normal limits. No granuloma or abnormal cells were found in any of the examined smears. Modified Ziehl-Neelsen staining showed numerous acid fast bacilli in the macrophages as well as outside the cells, mainly in the cell fragments (A). Additionally, small clusters of foamy histiocytes in the paratrabecular region with Wade-Fite stain positive lepra bacilli were observed (B). An acid fast bacilli culture using Lowenstein-Jensen medium was negative. A skin biopsy showed numerous foamy histiocytic granulomas admixed with lymphocytes and focally infiltrated by neutrophils in the dermis and subcutis. Therefore, a diagnosis of lepromatous leprosy with a type 2 reaction was made.
منابع مشابه
Sea blue histiocytosis: a common abnormality of the bone marrow in myelodysplastic syndromes.
AIMS To determine whether myelodysplastic syndromes (MDS) are associated with sea blue histiocytosis in the bone marrow. METHODS A retrospective review of bone marrow aspirates from 35 patients presenting consecutively with MDS and from 20 patients with each of the following: normal marrow appearance (routine staging for non-Hodgkin's lymphoma), polycythaemia rubra vera, immune thrombocytopen...
متن کاملSea-blue histiocytes and Gaucher cells in bone marrow of patients with chronic myeloid leukaemia.
A retrospective study of 211 bone marrow aspirates from patients with chronic myeloid leukaemia (CML) was undertaken to assess the incidence of Gaucher cells and sea-blue histiocytes. A significant correlation between the presence of these cells and prolonged survival was seen. Such storage histiocytes occurred most often during periods of relapsed chronic phase. This study shows that Gaucher c...
متن کاملFoamy histiocytes in a patient with visceral leishmaniasis after treatment with liposomal amphotericin B.
A seven-year-old patient was admitted to our hospital with the complaints of fever, malaise, and abdominal distention. In the bone marrow aspiration smears, leishmania amastigotes were observed. The patient was diagnosed as having visceral leishmaniasis (VL) and treated with liposomal amphotericin B (L-AMB). The authors report their observation of foamy histiocytes seen in the bone marrow aspir...
متن کاملPhagocytized Neutrophil Fragments in the Bone Marrow: A Phenomenon Most Commonly Associated with Hodgkin Lymphoma
Bone marrow macrophages containing other cells, or large pieces of other cells, represent a distinctive feature of diseases such as Hemophagocytic Lymphohistiocytosis (HLH) and Rosai-Dorfman disease. We describe a distinct variation of phagocytic histiocyte morphology, featuring histiocytes containing predominantly fragments of neutrophil nuclei. We retrospectively reviewed initial bone marrow ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 51 شماره
صفحات -
تاریخ انتشار 2016